Brett A. Colson, PhD

Assistant Professor, Biomedical Engineering
Associate Professor, BIO5 Institute
Associate Professor, Cellular and Molecular Medicine
Associate Professor, Clinical Translational Sciences
Associate Professor, Physiological Sciences - GIDP
Member of the Graduate Faculty
Research Interests: 

he Colson laboratory focuses on myofilament proteins that regulate contraction (e.g., MyBPC and MLC). He uses biophysical approaches, such as time-resolved spectroscopy with state-of-the art site directed probes to assess protein structural dynamics and mechanical measurements of isolated diseased muscle fibers. He has leveraged his technology into a high-throughput novel drug-discovery platform that is highly efficient and precise - accelerating the process of lead identification of drug candidates.

Selected Publications


Bunch, T. A., V. C. Lepak, R-S. Kanassatega, and B. A. Colson, "N-terminal extension in cardiac myosin-binding protein C regulates myofilament binding.", J Mol Cell Cardiol, vol. 125, pp. 140-148, 2018 Dec.