Professor, Cellular and Molecular Medicine
Professor, Molecular and Cellular Biology
Professor, Physiology
Professor, Physiological Sciences - GIDP
Professor, Biomedical Engineering - GIDP
Professor, BIO5 Institute
Allan and Alfie Norville Endowed Chair in Women’s Heart Disease
Research Interests:
Dr. Granzier’s laboratory investigates titin and its role in normal and abnormal heart function using bioengineering, physiology, and mechanical approaches. Focus areas of research include 1) intact cardiac myocyte mechanics and study of the changes in diastolic and systolic mechanics and calcium handling in response to beta-adrenergic signaling; 2) strain dependence of hypertrophy signaling in cardiac muscle; and 3) the role of titin in heart failure with preserved ejection fraction (HFpEF).